liver scarring research study poster

Liver Scarring Research Study

Have you been struggling to improve your liver health?
Benefits of Joining a Clinical Trial
  • Access to the study drug
  • Close care from a team of medical professionals at no cost
  • Helping doctors learn more about NASH/MASH and fibrosis, which may help others in the future
  • Participants will receive lifestyle counseling, study-related assessments, and medical monitoring
Gender
Male and Female
Ages
18-80
Compensation
$1,470.00
Status
Enrolling
See If You Qualify

Overview

Liver Scarring Research Study: Clinical Trial for NASH/MASH Liver Scarring

The study is a clinical trial for adults with non-cirrhotic nonalcoholic steatohepatitis (NASH) or metabolic dysfunction-associated steatohepatitis (MASH). NASH/MASH starts with a build-up of fat in the liver, damage to liver cells, and soreness, which eventually leads to scarring or cirrhosis.

The study will test an investigational drug to see whether it helps slow or possibly reverse fibrosis (scarring of the liver) and to learn about any side effects.

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About the Study

Find out more about a clinical trial of an investigational drug for nonalcoholic steatohepatitis (NASH)/metabolic dysfunction-associated steatohepatitis (MASH).

Participants will be randomly assigned (as if choosing names out of a hat) to take either a 28 mg /50 mg of the study medication or a placebo, which looks like the medicine but has no active ingredients. There is a 2 in 3 (66%) chance of getting the study drug, but you will not be able to choose. Whichever group you are in, you will give yourself an injection once a week, along with taking your usual medications. Your study doctor will teach you how to give yourself the injection.

Data protection of all participants is very important to us. We will take all precautions to keep participant identity and personal information safe.

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Who Can Join

You may be able to join the study if you:

  • Are from 18 to 80 years old
  • Have had a liver biopsy that showed NASH/MASH or are willing to undergo a biopsy
  • Have a BMI greater than 25
  • Have or ever had type 2 diabetes or 2 out of 4 signs of metabolic syndrome
    • overweight
    • have high cholesterol
    • elevated blood pressure
    • elevated fasting blood glucose

Not sure if you qualify?

A member of our study team will review your medical history and medications with you to determine if this study may be a good fit.

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What to Expect

Study Duration
The study lasts about 256 weeks

  • Study Phases:
    • 12-week screening period
    • followed by a treatment period of up to 240 weeks
    • followed by a follow-up visit 30 days after the last study dose

Study Visits
Approximately 36 study visits

Compensation

Compensation up to $1470 may be available for time and travel.

Procedures During the Study

Everyone in the study will need to have a liver tissue sample that shows they have NASH/MASH. A needle-core liver biopsy will be done at Week 52 (Cohort 1 only), Week 96 (Cohort 2 only) and compared against the screening biopsy. All subjects will undergo another liver biopsy at Week 240.

See If You Qualify

See if You Qualify.

To see if you qualify or to learn more, please complete the form

Frequently Asked Questions.

What is a Clinical Trial?

A clinical trial is a research study that evaluates new medications, devices, or treatment approaches to determine if they are safe and effective. Clinical trials help doctors and researchers develop better treatments for current and future patients. All studies follow strict safety guidelines and are carefully monitored.
Each clinical study has requirements for participants based on specific factors such as age, medical history and current health. The eligibility criteria in each study protocol are used to identify the volunteers best qualified to participate.
No. Study-related medications, tests, and medical visits are provided at no cost to you. Participation in a clinical trial should not require you to pay for study-related care.
Many studies provide compensation for time and travel. Compensation varies by study and will be explained before you decide to participate.
Health insurance is not required for most clinical trials. Study-related care is typically provided at no cost to you.
Participation is completely voluntary. You may choose to leave the study at any time, for any reason. Your decision will not affect your regular medical care or benefits.
Each study has specific eligibility criteria based on age, medical history, and other factors. The best way to find out if you qualify is to complete the eligibility form or speak with a research team member.
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